Abstrak:
Fibrosis in chronic wounds, such as chronic ulcers, is a major challenge in healing because it causes tissue stiffness, slows epithelialization, and reduces the patient's quality of life. The approach of using adjunctive therapy with topical creams based on zinc and chitosan shows potential in treating fibrosis and speeding up the healing process. This study aims to evaluate the effectiveness of additional therapy with topical zinc cream mixed with chitosan in reducing fibrosis and accelerating healing in patients with chronic ulcers. Methods the study was conducted on 5 patients aged 30 to 65 years who had chronic ulcers with significant fibrosis. The patient underwent a combination of additional therapy which included administration of adjunctive therapy including ozone therapy, inflared and daily application of topical zinc-chitosan cream once every 3 days for 10 weeks. Measurements were carried out using the Winner Scale to assess the reduction in fibrosis, increase in tissue elasticity, and speed of epithelialization. Results after 8 weeks of therapy, fibrosis was reduced by 45%, accompanied by a significant increase in tissue elasticity and faster epithelialization compared to conventional methods. The average score on the Winner Scale shows results in under 10 weeks, and there are reports of reduced pain and increased mobility from patients. Conclusion this study indicates that the combination of topical zinc cream and chitosan as additional therapy has high effectiveness in reducing fibrosis and accelerating the healing of chronic wounds. These results support the need for further research to explore the potential of zinc and chitosan as main components in the treatment of wounds with fibrosis.
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